Loss of ICA69 Potentiates Long-Lasting Hyperalgesia After Subcutaneous Formalin Injection into the Mouse Hindpaw

@article{Li2014LossOI,
  title={Loss of ICA69 Potentiates Long-Lasting Hyperalgesia After Subcutaneous Formalin Injection into the Mouse Hindpaw},
  author={Qian-Jun Li and Zhen Wang and Yong-xing Yao and Shen-Hui Jin and Mei-Zi Qian and Na-Na Li and Yanan Wang and Ya-Wen Zhang and Bin-yu Chen and Dan-yun Jia and Ying Shen and Junlu Wang},
  journal={Neurochemical Research},
  year={2014},
  volume={40},
  pages={579-590}
}
Islet-cell autoantigen 69 kDa (ICA69) plays an important role in many diseases and physiological activities by forming heteromeric complexes with protein interacts with C-kinase 1 (PICK1). PICK1 is critical for inflammatory pain hypersensitivity by regulating trafficking of AMPA receptor subunit GluA2 in spinal neurons. However, the role of ICA69 in inflammatory pain has not yet been investigated. Here we reported that expression of PICK1 in spinal cord was reduced largely in ICA69 knockout… CONTINUE READING
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croglial reactions after subcutaneous formalin injection into the rat hind paw

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