Loss of Heterozygosity and Promoter Methylation, but not Mutation, May Underlie Loss of TFF1 in Gastric Carcinoma

Abstract

It has been advanced that the trefoil factor (TFF) 1 gene is a candidate tumor-suppressor gene and may be involved in the development and/or progression of human gastric cancer. We aimed to clarify the putative role of TFF1 in gastric carcinogenesis. Ninety gastric carcinomas and eight gastric carcinoma-derived cell lines were screened for TFF1 mutations… (More)
DOI: 10.1097/01.LAB.0000029205.76632.A8

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Cite this paper

@article{Carvalho2002LossOH, title={Loss of Heterozygosity and Promoter Methylation, but not Mutation, May Underlie Loss of TFF1 in Gastric Carcinoma}, author={Ralph Carvalho and Tuncay Kayademir and Paula Soares and Paulo Canedo and S{\'o}nia Sousa and Carla Oliveira and Peter Leistenschneider and Raquel Seruca and Peter G{\"o}tt and Nikolaus Blin and F O A A Carneiro and J. Machado}, journal={Laboratory Investigation}, year={2002}, volume={82}, pages={1319-1326} }