Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis.

@article{Tang2004LossOH,
  title={Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis.},
  author={Nan Tang and Lianchun Wang and Jeffrey D Esko and Frank J. Giordano and Yan Huang and Howard L Gerber and Napoleone Ferrara and Randall S Johnson},
  journal={Cancer cell},
  year={2004},
  volume={6 5},
  pages={
          485-95
        }
}
We deleted the hypoxia-responsive transcription factor HIF-1alpha in endothelial cells (EC) to determine its role during neovascularization. We found that loss of HIF-1alpha inhibits a number of important parameters of EC behavior during angiogenesis: these include proliferation, chemotaxis, extracellular matrix penetration, and wound healing. Most strikingly, loss of HIF-1alpha in EC results in a profound inhibition of blood vessel growth in solid tumors. These phenomena are all linked to a… CONTINUE READING
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