Loss of Glial Lazarillo, a Homolog of Apolipoprotein D, Reduces Lifespan and Stress Resistance in Drosophila

@article{Snchez2006LossOG,
  title={Loss of Glial Lazarillo, a Homolog of Apolipoprotein D, Reduces Lifespan and Stress Resistance in Drosophila},
  author={Diego P S{\'a}nchez and Bego{\~n}a L{\'o}pez-Arias and Laura Torroja and Inmaculada Canal and Xiaohui Wang and Michael J. Bastiani and Maria D Ganfornina},
  journal={Current Biology},
  year={2006},
  volume={16},
  pages={680-686}
}
The vertebrate Apolipoprotein D (ApoD) is a lipocalin secreted from subsets of neurons and glia during neural development and aging . A strong correlation exists between ApoD overexpression and numerous nervous system pathologies as well as obesity, diabetes, and many forms of cancer . However, the exact relationship between the function of ApoD and the pathophysiology of these diseases is still unknown. We have generated loss-of-function Drosophila mutants for the Glial Lazarillo (GLaz) gene… CONTINUE READING

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