Loss of Gelsolin expression in human ovarian carcinomas.

  title={Loss of Gelsolin expression in human ovarian carcinomas.},
  author={Aurelia Noske and Carsten Denkert and Hagen Schober and Christine Sers and Bakhyt Zhumabayeva and Wilko Weichert and Manfred Dietel and Kai Wiechen},
  journal={European journal of cancer},
  volume={41 3},
The ubiquitously expressed actin-binding protein, gelsolin, is known to play a role in the modulation of the actin network and in the regulation of cell growth and cell motility. In the present study, we analysed the expression of gelsolin in 241 matched cDNA pairs from human normal and tumour tissues using a Cancer Profiling Array. We found a decreased expression of gelsolin in cancer tissue from female reproductive organs, including the ovary. On a protein level, we examined the expression of… CONTINUE READING


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