Loss of Gcn5l2 leads to increased apoptosis and mesodermal defects during mouse development

@article{Xu2000LossOG,
  title={Loss of Gcn5l2 leads to increased apoptosis and mesodermal defects during mouse development},
  author={Wanting Xu and Diane G. Edmondson and Yvonne A. Evrard and Maki Wakamiya and Richard R. Behringer and Sharon Y. Roth},
  journal={Nature Genetics},
  year={2000},
  volume={26},
  pages={229-232}
}
Histone acetyltransferases regulate transcription, but little is known about the role of these enzymes in developmental processes. Gcn5 (encoded by Gcn5l2) and Pcaf, mouse histone acetyltransferases, share similar sequences and enzymatic activities. Both interact with p300 and CBP (encoded by Ep300 and Crebbp, respectively), two other histone acetyltransferases that integrate multiple signalling pathways. Pcaf is thought to participate in many of the cellular processes regulated by p300/CBP… CONTINUE READING
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Differential roles of p300 and PCAF acetyltransferases in muscle differentiation

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