Loss of GLUR2 alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid receptor subunit differentially affects remaining synaptic glutamate receptors in cerebellum and cochlear nuclei.

@article{Petralia2004LossOG,
  title={Loss of GLUR2 alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid receptor subunit differentially affects remaining synaptic glutamate receptors in cerebellum and cochlear nuclei.},
  author={Ronald S. Petralia and Nathalie Sans and Ya-xian Wang and Bryce Vissel and Kai Ming Chang and Konrad Noben-Trauth and Stephen F. Heinemann and Robert J. Wenthold},
  journal={The European journal of neuroscience},
  year={2004},
  volume={19 8},
  pages={2017-29}
}
The alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid (AMPA) type of ionotropic glutamate receptor is the major mediator of fast neurotransmission in the brain and spinal cord. Most AMPA receptors are impermeable to calcium because they contain the GluR2 subunit. However, some AMPA receptors lack GluR2 and pass calcium which can mediate synaptic plasticity and, in excess, neurotoxicity. Previously, we showed a decrease in the density of synaptic AMPA receptors in the hippocampus of mice… CONTINUE READING