Loss of GGN Leads to Pre-Implantation Embryonic Lethality and Compromised Male Meiotic DNA Double Strand Break Repair in the Mouse

@inproceedings{Jamsai2013LossOG,
  title={Loss of GGN Leads to Pre-Implantation Embryonic Lethality and Compromised Male Meiotic DNA Double Strand Break Repair in the Mouse},
  author={Duangporn Jamsai and Anne E. O’Connor and Kathleen D. DeBoer and Brett J. Clark and Stephanie J. Smith and Catherine M. Browne and Jonathan G Bensley and Julie A. Merriman and Wai Shan Yuen and Peter Koopman and Keith T Jones and Moira K. O’Bryan},
  booktitle={PloS one},
  year={2013}
}
The integrity of male germ cell genome is critical for the correct progression of spermatogenesis, successful fertilization, and proper development of the offspring. Several DNA repair pathways exist in male germ cells. However, unlike somatic cells, key components of such pathways remain largely unidentified. Gametogenetin (GGN) is a testis-enriched protein that has been shown to bind to the DNA repair protein FANCL via yeast-two-hybrid assays. This finding and its testis-enriched expression… CONTINUE READING

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