Loss of G(1)/S checkpoint in human immunodeficiency virus type 1-infected cells is associated with a lack of cyclin-dependent kinase inhibitor p21/Waf1.

@article{Clark2000LossOG,
  title={Loss of G(1)/S checkpoint in human immunodeficiency virus type 1-infected cells is associated with a lack of cyclin-dependent kinase inhibitor p21/Waf1.},
  author={Elizabeth C. Clark and Francisco Javier de Santiago and L. W. Deng and Siew Yen Chong and Cynthia de la Fuente and Ling Wang and Peng Fu and David Stein and T Denny and Venkata K. Lanka and Fariba S. Mozafari and Tetsugaku Okamoto and Fatah Kashanchi},
  journal={Journal of virology},
  year={2000},
  volume={74 11},
  pages={
          5040-52
        }
}
Productive high-titer infection by human immunodeficiency virus type 1 (HIV-1) requires the activation of target cells. Infection of quiescent peripheral CD4 lymphocytes by HIV-1 results in incomplete, labile reverse transcripts and lack of viral progeny formation. An interplay between Tat and p53 has previously been reported, where Tat inhibited the transcription of the p53 gene, which may aid in the development of AIDS-related malignancies, and p53 expression inhibited HIV-1 long terminal… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 32 CITATIONS

Novel HIV-1 therapeutics through targeting altered host cell pathways.

  • Expert opinion on biological therapy
  • 2009
VIEW 6 EXCERPTS
CITES BACKGROUND & METHODS

Drug 9AA reactivates p21/Waf1 and Inhibits HIV-1 progeny formation

  • Virology Journal
  • 2008
VIEW 10 EXCERPTS
CITES BACKGROUND & RESULTS

Role of viral regulatory and accessory proteins in HIV-1 replication.

  • Frontiers in bioscience : a journal and virtual library
  • 2004
VIEW 17 EXCERPTS
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 50 REFERENCES

The tumor suppressor protein p53 strongly alters human immunodeficiency virus type 1 replication

L. Duan, I. Ozaki, +3 authors R. J. Pomerantz
  • J. Virol
  • 1994
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Cell-cycle signaling: Atm displays its many talents

  • Current Biology
  • 1997
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Inhibitors of cyclin-dependent kinase and cancer

  • Journal of Molecular Medicine
  • 1995
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Reciprocal modulations between p53 and Tat of human immunodeficiency virus type 1.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 1995
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL