Loss-of-Function Mutation in Myostatin Reduces Tumor Necrosis Factor α Production and Protects Liver Against Obesity-Induced Insulin Resistance

@article{Wilkes2009LossofFunctionMI,
  title={Loss-of-Function Mutation in Myostatin Reduces Tumor Necrosis Factor α Production and Protects Liver Against Obesity-Induced Insulin Resistance},
  author={Jason J. Wilkes and David J. B. Lloyd and Nick Gekakis},
  journal={Diabetes},
  year={2009},
  volume={58},
  pages={1133 - 1143}
}
OBJECTIVE Insulin resistance develops in tandem with obesity. Ablating myostatin (Mstn) prevents obesity, so we investigated if Mstn deficiency could improve insulin sensitivity. A loss-of-function mutation (Mstn(Ln)) in either one or both alleles of the Mstn gene shows how Mstn deficiency protects whole-body insulin sensitivity. RESEARCH DESIGN AND METHODS Mstn(Ln/Ln) mice were weaned onto a high-fat diet (HFD) or standard diet. HFD-fed Mstn(Ln/Ln) mice exhibited high lean, low-fat body… CONTINUE READING

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References

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FSTL3 deletion reveals roles for TGF-beta family ligands in glucose and fat homeostasis in adults.

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