Loss of FilaminC (FLNc) results in severe defects in myogenesis and myotube structure.

@article{Dalkilic2006LossOF,
  title={Loss of FilaminC (FLNc) results in severe defects in myogenesis and myotube structure.},
  author={Isin Dalkilic and Jaclyn Schienda and Terri Thompson and Louis M. Kunkel},
  journal={Molecular and cellular biology},
  year={2006},
  volume={26 17},
  pages={6522-34}
}
FilaminC (FLNc) is the muscle-specific member of a family of actin binding proteins. Although it interacts with many proteins involved in muscular dystrophies, its unique role in muscle is poorly understood. To address this, two models were developed. First, FLNc expression was stably reduced in C2C12 myoblasts by RNA interference. While these cells start differentiation normally, they display defects in differentiation and fusion ability and ultimately form multinucleated "myoballs" rather… CONTINUE READING