Loss of Fbw7 Reprograms Adult Pancreatic Ductal Cells into α, δ, and β Cells

@inproceedings{Sancho2014LossOF,
  title={Loss of Fbw7 Reprograms Adult Pancreatic Ductal Cells into α, δ, and β Cells},
  author={Roc{\'i}o Sancho and Ralph Gruber and Guoqiang Gu and Axel Behrens},
  booktitle={Cell stem cell},
  year={2014}
}
The adult pancreas is capable of limited regeneration after injury but has no defined stem cell population. The cell types and molecular signals that govern the production of new pancreatic tissue are not well understood. Here, we show that inactivation of the SCF-type E3 ubiquitin ligase substrate recognition component Fbw7 induces pancreatic ductal cells… CONTINUE READING