Loss of Endothelial Nitric Oxide Synthase Promotes p25 Generation and Tau Phosphorylation in a Murine Model of Alzheimer's Disease.

@article{Austin2016LossOE,
  title={Loss of Endothelial Nitric Oxide Synthase Promotes p25 Generation and Tau Phosphorylation in a Murine Model of Alzheimer's Disease.},
  author={Susan A. Austin and Zvonimir S. Katu{\vs}i{\'c}},
  journal={Circulation research},
  year={2016},
  volume={119 10},
  pages={
          1128-1134
        }
}
RATIONALE Alzheimer's disease has an unknown pathogenesis; however, cardiovascular risk factors are associated with a higher incidence of Alzheimer's disease. A defining feature of endothelial dysfunction induced by cardiovascular risk factors is reduced bioavailable endothelial nitric oxide (NO). We previously demonstrated that endothelial NO acts as an important signaling molecule in neuronal tissue. OBJECTIVE We sought to determine the relationship between the loss of endothelial NO… CONTINUE READING
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