Loss of ERα partially reverses the effects of maternal high-fat diet on energy homeostasis in female mice

@inproceedings{Roepke2017LossOE,
  title={Loss of ERα partially reverses the effects of maternal high-fat diet on energy homeostasis in female mice},
  author={Troy A Roepke and Ali Yasrebi and Alejandra Rodr{\'i}guez Villalobos and Elizabeth Ann Krumm and Jennifer A. Yang and Kyle J Mamounis},
  booktitle={Scientific Reports},
  year={2017}
}
Maternal high-fat diet (HFD) alters hypothalamic developmental programming and disrupts offspring energy homeostasis in rodents. 17β-estradiol (E2) also influences hypothalamic programming through estrogen receptor (ER) α. Therefore, we hypothesized that females lacking ERα would be more susceptible to maternal HFD. To address this question, heterozygous ERα knockout (WT/KO) dams were fed a control breeder chow diet (25% fat) or a semi-purified HFD (45% fat) 4 weeks prior to mating with WT/KO… CONTINUE READING
BETA
5
Twitter Mentions

References

Publications referenced by this paper.
SHOWING 1-10 OF 108 REFERENCES

AgRP to Kiss1 neuron signaling links nutritional state and fertility.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2017

Effects of a maternal high-fat diet on offspring behavioral and metabolic parameters in a rodent model

S Johnson
  • J Dev Orig Health Dis
  • 2017

Silencing via DNA Methylation of Basal, Stem Cell, and EMT Genes

Ariazi, E. A. et al. A New Role for ERα
  • Mol Cancer Res 15, 152–164
  • 2016

Similar Papers

Loading similar papers…