Loss of E-cadherin expression in melanoma cells involves up-regulation of the transcriptional repressor Snail.

@article{Poser2001LossOE,
  title={Loss of E-cadherin expression in melanoma cells involves up-regulation of the transcriptional repressor Snail.},
  author={Ina Poser and David Jorge Dom{\'i}nguez and Antonio Garc{\'i}a de Herreros and Anik{\'o} V{\'a}rnai and Reinhard Mechoulam Raphael Buettner and Anja Kathrin Bosserhoff},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 27},
  pages={
          24661-6
        }
}
Malignant transformation of melanocytes frequently coincides with loss of E-cadherin expression. Here we show that loss of E-cadherin in melanoma cell lines does not involve mutations in the E-cadherin gene, promoter methylation, or alterations in expression of AP-2 transcription factors as suggested previously. In a panel of different melanoma cell lines, E-cadherin expression was negatively regulated by up-regulation of the transcription factor Snail. In comparison with primary human… CONTINUE READING
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