Loss of E-cadherin-dependent cell-cell adhesion due to mutation of the beta-catenin gene in a human cancer cell line, HSC-39.

@article{Kawanishi1995LossOE,
  title={Loss of E-cadherin-dependent cell-cell adhesion due to mutation of the beta-catenin gene in a human cancer cell line, HSC-39.},
  author={Johji Kawanishi and Jun-ya Kato and Koichi Sasaki and Satoshi Fujii and Norihiko Watanabe and Yoshiro Niitsu},
  journal={Molecular and cellular biology},
  year={1995},
  volume={15 3},
  pages={
          1175-81
        }
}
Detachment of cell-cell adhesion is indispensable for the first step of invasion and metastasis of cancer. This mechanism is frequently associated with the impairment of either E-cadherin expression or function. However, mechanisms of such abnormalities have not been fully elucidated. In this study, we demonstrated that the function of E-cadherin was completely abolished in the human gastric cancer cell line HSC-39, despite the high expression of E-cadherin, because of mutations in one of the E… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 70 CITATIONS

FILTER CITATIONS BY YEAR

1995
2018

CITATION STATISTICS

  • 1 Highly Influenced Citations

  • Averaged 3 Citations per year over the last 3 years

  • 14% Increase in citations per year in 2018 over 2017

Similar Papers

Loading similar papers…