Loss of Dopamine Transporters in Methamphetamine Abusers Recovers with Protracted Abstinence

  title={Loss of Dopamine Transporters in Methamphetamine Abusers Recovers with Protracted Abstinence},
  author={N. Volkow and L. Chang and G. Wang and J. Fowler and D. Franceschi and M. Sedler and S. Gatley and E. Miller and R. Hitzemann and Y. Ding and J. Logan},
  journal={The Journal of Neuroscience},
  pages={9414 - 9418}
  • N. Volkow, L. Chang, +8 authors J. Logan
  • Published 2001
  • Psychology, Medicine
  • The Journal of Neuroscience
  • Methamphetamine is a popular drug of abuse that is neurotoxic to dopamine (DA) terminals when administered to laboratory animals. Studies in methamphetamine abusers have also documented significant loss of DA transporters (used as markers of the DA terminal) that are associated with slower motor function and decreased memory. The extent to which the loss of DA transporters predisposes methamphetamine abusers to neurodegenerative disorders such as Parkinsonism is unclear and may depend in part… CONTINUE READING
    590 Citations
    Partial recovery of brain metabolism in methamphetamine abusers after protracted abstinence.
    • 221
    Decreased dopamine activity predicts relapse in methamphetamine abusers
    • 163
    • PDF
    Cognitive function and nigrostriatal markers in abstinent methamphetamine abusers
    • 86
    • Highly Influenced
    • PDF
    Rapid Recovery of Vesicular Dopamine Levels in Methamphetamine Users in Early Abstinence
    • 11
    Brain serotonin transporter density and aggression in abstinent methamphetamine abusers.
    • 238
    • PDF
    Dysregulation of D2-Mediated Dopamine Transmission in Monkeys after Chronic Escalating Methamphetamine Exposure
    • 70
    • Highly Influenced
    • PDF


    Association of dopamine transporter reduction with psychomotor impairment in methamphetamine abusers.
    • 835
    Recovery from methamphetamine induced long-term nigrostriatal dopaminergic deficits without substantia nigra cell loss
    • 120
    • Highly Influential
    • PDF
    Striatal dopamine nerve terminal markers in human, chronic methamphetamine users
    • 677
    Recovery of striatal dopamine function after acute amphetamine- and methamphetamine-induced neurotoxicity in the vervet monkey
    • 124
    • Highly Influential
    Age as a Susceptibility Factor in the Striatal Dopaminergic Neurotoxicity Observed in the Mouse following Substituted Amphetamine Exposure
    • 36
    Elevated striatal dopamine transporters during acute cocaine abstinence as measured by [123I] beta-CIT SPECT.
    • 148
    • PDF
    Dopamine transporters decrease with age.
    • N. Volkow, Y. Ding, +7 authors R. Gur
    • Medicine
    • Journal of nuclear medicine : official publication, Society of Nuclear Medicine
    • 1996
    • 250
    Amphetamine-induced loss of human dopamine transporter activity: an internalization-dependent and cocaine-sensitive mechanism.
    • C. Saunders, J. Ferrer, +7 authors A. Galli
    • Chemistry, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 2000
    • 382
    • PDF