Loss of Dopamine D2 Receptors Increases Parvalbumin-Positive Interneurons in the Anterior Cingulate Cortex

@inproceedings{Graham2015LossOD,
  title={Loss of Dopamine D2 Receptors Increases Parvalbumin-Positive
Interneurons in the Anterior Cingulate Cortex},
  author={Devon R. Graham and Heather H. Durai and Jamie D. Garden and Evan L. Cohen and Franklin D. Echevarria and Gregg David Stanwood},
  booktitle={ACS chemical neuroscience},
  year={2015}
}
Disruption to dopamine homeostasis during brain development has been implicated in a variety of neuropsychiatric disorders, including depression and schizophrenia. Inappropriate expression or activity of GABAergic interneurons are common features of many of these disorders. We discovered a persistent upregulation of GAD67+ and parvalbumin+ neurons within the anterior cingulate cortex of dopamine D2 receptor knockout mice, while other GABAergic interneuron markers were unaffected. Interneuron… CONTINUE READING
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