Loss of DNA loop supercoiling and organization in cells infected by herpes simplex virus type 1.

@article{ArandaAnzaldo1997LossOD,
  title={Loss of DNA loop supercoiling and organization in cells infected by herpes simplex virus type 1.},
  author={Armando Aranda-Anzaldo and Myrna A. R. Dent},
  journal={Research in virology},
  year={1997},
  volume={148 6},
  pages={397-408}
}
In cells infected by herpesviruses, a sequence of nuclear changes during interphase, as well as chromosomal aberrations during mitosis, are commonly observed. These changes suggest the progressive modification of host-cell chromatin. Previous studies have shown that the early chromatin modifications in cells infected by herpes simplex virus type 1 (HSV1) are not due to extensive breakdown of host-cell DNA or disruption of the nucleosomal structure. We have previously shown that infection by… CONTINUE READING