Loss of DJ-1 impairs antioxidant response by altered glutamine and serine metabolism

@article{Meiser2016LossOD,
  title={Loss of DJ-1 impairs antioxidant response by altered glutamine and serine metabolism},
  author={Johannes Meiser and S{\'e}bastien Delcambre and Anja Wegner and Carsten Jaeger and Jenny Ghelfi and Aymeric Fouquier d'H{\'e}rouel and Xinzhong Dong and Daniel Weindl and C. Stautner and Yannic Nonnenmacher and Alessandro Michelucci and Oliver Popp and Florian Giesert and Stefan Schildknecht and Laura S Kraemer and Jochen G. Schneider and Dirk Woitalla and Wolfgang Wurst and Alexander Skupin and Daniela M. Vogt Weisenhorn and Rejko Krueger and Marcel Leist and Karla Hiller},
  journal={Neurobiology of Disease},
  year={2016},
  volume={89},
  pages={112-125}
}
The oncogene DJ-1 has been originally identified as a suppressor of PTEN. Further on, loss-of-function mutations have been described as a causative factor in Parkinson's disease (PD). DJ-1 has an important function in cellular antioxidant responses, but its role in central metabolism of neurons is still elusive. We applied stable isotope assisted metabolic profiling to investigate the effect of a functional loss of DJ-1 and show that DJ-1 deficient neuronal cells exhibit decreased glutamine… CONTINUE READING
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