Loss of Cystic Fibrosis Transmembrane Regulator Impairs Intestinal Oxalate Secretion.

  title={Loss of Cystic Fibrosis Transmembrane Regulator Impairs Intestinal Oxalate Secretion.},
  author={Felix Knauf and Robert B Thomson and John F. Heneghan and Zhirong Jiang and Adedotun Adebamiro and Claire L Thomson and Christina Barone and John R. Asplin and Marie E Egan and Seth L Alper and Peter S. Aronson},
  journal={Journal of the American Society of Nephrology : JASN},
  volume={28 1},
Patients with cystic fibrosis have an increased incidence of hyperoxaluria and calcium oxalate nephrolithiasis. Net intestinal absorption of dietary oxalate results from passive paracellular oxalate absorption as modified by oxalate back secretion mediated by the SLC26A6 oxalate transporter. We used mice deficient in the cystic fibrosis transmembrane conductance regulator gene (Cftr) to test the hypothesis that SLC26A6-mediated oxalate secretion is defective in cystic fibrosis. We mounted… CONTINUE READING
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