Loss of CtIP disturbs homologous recombination repair and sensitizes breast cancer cells to PARP inhibitors

@inproceedings{Wang2016LossOC,
  title={Loss of CtIP disturbs homologous recombination repair and sensitizes breast cancer cells to PARP inhibitors},
  author={Junhui Wang and Qianshan Ding and Hiroaki Fujimori and Akira Motegi and Yoshio Miki and Mitsuko Masutani},
  booktitle={Oncotarget},
  year={2016}
}
Breast cancer is one of the leading causes of death worldwide, and therefore, new and improved approaches for the treatment of breast cancer are desperately needed. CtIP (RBBP8) is a multifunctional protein that is involved in various cellular functions, including transcription, DNA replication, DNA repair and the G1 and G2 cell cycle checkpoints. CtIP plays an important role in homologous recombination repair by interacting with tumor suppressor protein BRCA1. Here, we analyzed the expression… CONTINUE READING
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