Loss of Co-ordinate Expression of Progesterone Receptors A and B is an Early Event in Breast Carcinogenesis

@article{Mote2002LossOC,
  title={Loss of Co-ordinate Expression of Progesterone Receptors A and B is an Early Event in Breast Carcinogenesis},
  author={Patricia A. Mote and Sue Bartow and Nicholas Tran and Christine L. Clarke},
  journal={Breast Cancer Research and Treatment},
  year={2002},
  volume={72},
  pages={163-172}
}
Progesterone receptor (PR) mediates the effects of progesterone in mammary tissues and plays a crucial role in normal breast development and in breast cancer. PR proteins are expressed as two isoforms, PRA and PRB, that have different capacities to activate target genes, yet it is unknown whether progesterone action in normal and malignant breast is mediated by PRA and/or PRB. This study determines the relative expression of PRA and PRB in normal breast and in benign, premalignant and malignant… CONTINUE READING
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