Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in β-islet cell hyperplasia

@article{Rane1999LossOC,
  title={Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in $\beta$-islet cell hyperplasia},
  author={Sushil G. Rane and Pierre Dubus and Richard V. Mettus and Elizabeth J. Galbreath and Guenther H. Boden and E. P. Reddy and Mariano Barbacid},
  journal={Nature Genetics},
  year={1999},
  volume={22},
  pages={44-52}
}
To ascertain the role of cyclin-dependent kinase 4 (Cdk4) in vivo, we have targeted the mouse Cdk4 locus by homologous recombination to generate two strains of mice, one that lacks Cdk4 expression and one that expresses a Cdk4 molecule with an activating mutation. Embryonic fibroblasts proliferate normally in the absence of Cdk4 but have a delayed S phase on re-entry into the cell cycle. Moreover, mice devoid of Cdk4 are viable, but small in size and infertile. These mice also develop insulin… Expand
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