Loss of Cartilage Structure, Stiffness, and Frictional Properties in Mice Lacking PRG4

@inproceedings{Coles2010LossOC,
  title={Loss of Cartilage Structure, Stiffness, and Frictional Properties in Mice Lacking PRG4},
  author={Jeffrey M. Coles and Ling Zhang and Jason J. Blum and Matthew L Warman and Gregory D. Jay and Farshid Guilak and Stefan Zauscher},
  booktitle={Arthritis and rheumatism},
  year={2010}
}
OBJECTIVE To assess the role of the glycoprotein PRG4 in joint lubrication and chondroprotection by measuring friction, stiffness, surface topography, and subsurface histology of the hip joints of Prg4(-/-) and wild-type (WT) mice. METHODS Friction and elastic modulus were measured in cartilage from the femoral heads of Prg4(-/-) and WT mice ages 2, 4, 10, and 16 weeks using atomic force microscopy, and the surface microstructure was imaged. Histologic sections of each femoral head were… CONTINUE READING

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Roles of adsorbed film and gel layer in hydration lubrication for articular cartilage

  • T Murakami, K Nakashima, Y Sawae, N Sakai, N. Hosoda
  • Proc Inst Mech Eng J 2009;223:287–95
  • 2009
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