Loss of CTL function among high-avidity tumor-specific CD8+ T cells following tumor infiltration.

@article{Janicki2008LossOC,
  title={Loss of CTL function among high-avidity tumor-specific CD8+ T cells following tumor infiltration.},
  author={C. Janicki and S. Jenkinson and N. Williams and D. Morgan},
  journal={Cancer research},
  year={2008},
  volume={68 8},
  pages={
          2993-3000
        }
}
A major problem in generating effective antitumor CTL responses is that most tumors express self-antigens to which the immune system is rendered unresponsive due to mechanisms of self-tolerance induction. CTL precursors (CTLp) expressing high-affinity T-cell receptors (TCR) are often functionally deleted from the repertoire, leaving a residual repertoire of CTLp having only low-affinity TCR. Furthermore, even when unique antigens are expressed, their presentation by dendritic cells (DC) may… Expand
71 Citations
High-avidity T cells are preferentially tolerized in the tumor microenvironment.
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