Loss of CSMD1 expression is associated with high tumour grade and poor survival in invasive ductal breast carcinoma

@article{Kamal2009LossOC,
  title={Loss of CSMD1 expression is associated with high tumour grade and poor survival in invasive ductal breast carcinoma},
  author={Mohamed K Kamal and Abeer Adel Mohammed Shaaban and Liqun Zhang and Clare Walker and Sally Gray and Nalin S. Thakker and Carmel Toomes and Valerie Speirs and Sandra M. Bell},
  journal={Breast Cancer Research and Treatment},
  year={2009},
  volume={121},
  pages={555-563}
}
CUB and SUSHI multiple domain protein 1 (CSMD1) is a candidate tumour suppressor gene that maps to chromosome 8p23, a region deleted in many tumour types including 50% of breast cancers. CSMD1 has homologies to proteins implicated in carcinogenesis. We aimed to study the expression pattern of the CSMD1 protein and evaluate its prognostic importance in invasive ductal carcinoma (IDC). An anti-CSMD1 antibody was developed and validated. The expression pattern of CSMD1 in normal breast and IDC… CONTINUE READING