Loss of CFTR chloride channels alters salt absorption by cystic fibrosis airway epithelia in vitro.

@article{Zabner1998LossOC,
  title={Loss of CFTR chloride channels alters salt absorption by cystic fibrosis airway epithelia in vitro.},
  author={Joseph Zabner and Jeffrey John Smith and Philip H. Karp and Jonathan H. Widdicombe and Michael J. Welsh},
  journal={Molecular cell},
  year={1998},
  volume={2 3},
  pages={
          397-403
        }
}
Cystic fibrosis (CF) is caused by the loss of functional CFTR Cl- channels. However, it is not understood how this defect disrupts salt and liquid movement in the airway or whether it alters the NaCl concentration in the thin liquid film covering the airway surface. Using a new approach, we found that CF airway surface liquid had a higher NaCl concentration than normal. Both CF and non-CF epithelia absorbed salt and liquid; however, expression of CFTR Cl- channels was required for maximal… CONTINUE READING
BETA

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 107 CITATIONS

A mathematical model of calcium-induced fluid secretion in airway epithelium.

  • Journal of theoretical biology
  • 2009
VIEW 6 EXCERPTS
CITES BACKGROUND, RESULTS & METHODS
HIGHLY INFLUENCED

Altered NaCl Concentration of Airway Surface Liquid in Cystic Fibrosis

VIEW 3 EXCERPTS
CITES RESULTS & BACKGROUND
HIGHLY INFLUENCED

Efficient killing of inhaled bacteria in ΔF508 mice: role of airway surface liquid composition.

  • American journal of physiology. Lung cellular and molecular physiology
  • 1999
VIEW 5 EXCERPTS
CITES METHODS, RESULTS & BACKGROUND
HIGHLY INFLUENCED

Fluid absorption related to ion transport in human airway epithelial spheroids.

  • American journal of physiology. Lung cellular and molecular physiology
  • 1999
VIEW 5 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

Salt and Microbiota : Respiratory Tract Microbiota of Cystic Fibrosis Patients

Mariama Marou, Drancourt Michel
  • 2019
VIEW 1 EXCERPT
CITES BACKGROUND

FILTER CITATIONS BY YEAR

1998
2019

CITATION STATISTICS

  • 6 Highly Influenced Citations

  • Averaged 4 Citations per year over the last 3 years

Similar Papers

Loading similar papers…