Loss of CFTR affects biliary epithelium innate immunity and causes TLR4-NF-κB-mediated inflammatory response in mice.

@article{Fiorotto2011LossOC,
  title={Loss of CFTR affects biliary epithelium innate immunity and causes TLR4-NF-κB-mediated inflammatory response in mice.},
  author={Romina Fiorotto and Roberto Scirpo and Michael Trauner and Luca Fabris and Rafaz Hoque and Carlo Spirl{\'i} and Mario Strazzabosco},
  journal={Gastroenterology},
  year={2011},
  volume={141 4},
  pages={1498-508, 1508.e1-5}
}
BACKGROUND & AIMS Loss of function of the cystic fibrosis transmembrane conductance regulator (CFTR) in the biliary epithelium reduces bile flow and alkalinization in patients with cystic fibrosis (CF). Liver damage is believed to result from ductal cholestasis, but only 30% of patients with CF develop liver defects, indicating that another factor is involved. We studied the effects of CFTR deficiency on Toll-like receptor 4 (TLR4)-mediated responses of the biliary epithelium to endotoxins… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 36 extracted citations

Similar Papers

Loading similar papers…