Loss of CD73-mediated extracellular adenosine production exacerbates inflammation and abnormal alveolar development in newborn mice exposed to prolonged hyperoxia

@article{Li2017LossOC,
  title={Loss of CD73-mediated extracellular adenosine production exacerbates inflammation and abnormal alveolar development in newborn mice exposed to prolonged hyperoxia},
  author={Huiling Li and Harry Karmouty-Quintana and Ning-yuan Chen and Tingting Weng Mills and Jos{\'e} Molina and Michael R. Blackburn and J. T. Davies},
  journal={Pediatric Research},
  year={2017},
  volume={82},
  pages={1039-1047}
}
BackgroundHyperoxic lung injury is characterized by cellular damage from high oxygen concentrations that lead to an inflammatory response and it disrupts normal alveolarization in the developing newborn lung. Adenosine is a signaling molecule that is generated extracellularly by ecto-5′-nucleotidase (CD73) in response to injury. Extracellular adenosine signals through cell surface receptors and has been found to have a protective role in acute injury situations; however, chronic elevations have… CONTINUE READING