Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells.

@article{Akbar1988LossOC,
  title={Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells.},
  author={Arne N. Akbar and Luther L. Terry and A Timms and Peter Beverley and George Janossy},
  journal={Journal of immunology},
  year={1988},
  volume={140 7},
  pages={2171-8}
}
A group of mAb recognizing the 200- and/or 220-kDa determinants (CD45R) of the leukocyte common Ag such as 2H4, WR16, MD4.3, and SN130 cross-block each other showing that they recognize a closely related epitope. The antibody UCHL1 reacts with a 180-kDa determinant of the leukocyte common Ag and exhibits a reciprocal T subset distribution pattern to the CD45R group. Peripheral blood T cells were 40% positive for UCHL1 and 58 to 65% positive for the CD45R antibodies; less than 1% of cells… CONTINUE READING

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