Loss of BNIP3 expression is a late event in pancreatic cancer contributing to chemoresistance and worsened prognosis

@article{Erkan2005LossOB,
  title={Loss of BNIP3 expression is a late event in pancreatic cancer contributing to chemoresistance and worsened prognosis},
  author={Mert Erkan and Joerg Kleeff and Irene Esposito and Thomas Giese and Knut Ketterer and Markus W. B{\"u}chler and Nathalla A Giese and Helmut Friess},
  journal={Oncogene},
  year={2005},
  volume={24},
  pages={4421-4432}
}
Altered expression of apoptosis-regulating genes plays an important role in the aggressive growth behavior and chemoresistance of pancreatic ductal adenocarcinoma. In the present study, the hypoxia-inducible proapoptotic gene, BNIP3, was analysed in terms of expression, effect on patient survival, and chemo-responsiveness in pancreatic cancer cell lines. cDNA microarray, real-time light cycler® quantitative polymerase chain reaction, laser-capture microdissection, and immunohistochemistry… CONTINUE READING

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