Loss of BNIP3 expression is a late event in pancreatic cancer contributing to chemoresistance and worsened prognosis

  title={Loss of BNIP3 expression is a late event in pancreatic cancer contributing to chemoresistance and worsened prognosis},
  author={M. Erkan and J. Kleeff and I. Esposito and T. Giese and K. Ketterer and M. B{\"u}chler and Nathalla A Giese and H. Friess},
  • M. Erkan, J. Kleeff, +5 authors H. Friess
  • Published 2005
  • Biology, Medicine
  • Oncogene
  • Altered expression of apoptosis-regulating genes plays an important role in the aggressive growth behavior and chemoresistance of pancreatic ductal adenocarcinoma. In the present study, the hypoxia-inducible proapoptotic gene, BNIP3, was analysed in terms of expression, effect on patient survival, and chemo-responsiveness in pancreatic cancer cell lines. cDNA microarray, real-time light cycler® quantitative polymerase chain reaction, laser-capture microdissection, and immunohistochemistry… CONTINUE READING
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