Loss of BAF (mSWI/SNF) Complexes Causes Global Transcriptional and Chromatin State Changes in Forebrain Development.

@article{Narayanan2015LossOB,
  title={Loss of BAF (mSWI/SNF) Complexes Causes Global Transcriptional and Chromatin State Changes in Forebrain Development.},
  author={Ramanathan Narayanan and Mehdi Pirouz and Cemil Kerimoglu and Linh Hung Pham and Robin Jan Wagener and Kamila A. Kiszka and Joachim Rosenbusch and Rho Hyun Seong and M. A. P. Kessel and Andre Fischer and Anastassia Stoykova and Jochen F. Staiger and Tran Tuoc},
  journal={Cell reports},
  year={2015},
  volume={13 9},
  pages={
          1842-54
        }
}
BAF (Brg/Brm-associated factors) complexes play important roles in development and are linked to chromatin plasticity at selected genomic loci. Nevertheless, a full understanding of their role in development and chromatin remodeling has been hindered by the absence of mutants completely lacking BAF complexes. Here, we report that the loss of BAF155/BAF170 in double-conditional knockout (dcKO) mice eliminates all known BAF subunits, resulting in an overall reduction in active chromatin marks… CONTINUE READING
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