Loss of B-cell translocation gene-2 in estrogen receptor-positive breast carcinoma is associated with tumor grade and overexpression of cyclin d1 protein.

@article{Kawakubo2006LossOB,
  title={Loss of B-cell translocation gene-2 in estrogen receptor-positive breast carcinoma is associated with tumor grade and overexpression of cyclin d1 protein.},
  author={Hirofumi Kawakubo and Elena F. Brachtel and Tetsu Hayashida and Giminna Yeo and Joshua Kish and Alona Muzikansky and Paul D. Walden and S. Maheswaran},
  journal={Cancer research},
  year={2006},
  volume={66 14},
  pages={7075-82}
}
The B-cell translocation gene-2 (BTG2) is present in the nuclei of epithelial cells in many tissues, including the mammary gland where its expression is regulated during glandular proliferation and differentiation in pregnancy. In immortalized mammary epithelial cells and breast cancer cells, BTG2 protein localized predominantly to the nucleus and cytoplasm, respectively. The highly conserved domains (BTG boxes A, B, and C) were required for regulating localization, suppression of cyclin D1 and… CONTINUE READING