Loss of Apm1, the micro1 subunit of the clathrin-associated adaptor-protein-1 complex, causes distinct phenotypes and synthetic lethality with calcineurin deletion in fission yeast.

@article{Kita2004LossOA,
  title={Loss of Apm1, the micro1 subunit of the clathrin-associated adaptor-protein-1 complex, causes distinct phenotypes and synthetic lethality with calcineurin deletion in fission yeast.},
  author={Ayako Kita and Reiko Sugiura and Hiromi Shoji and Yi He and Lu Deng and Yabin Lu and Susie Ong Sio and Kaoru Takegawa and Motoyoshi Sakaue and Hisato Shuntoh and Takayoshi Kuno},
  journal={Molecular biology of the cell},
  year={2004},
  volume={15 6},
  pages={
          2920-31
        }
}
Calcineurin is a highly conserved regulator of Ca(2+) signaling in eukaryotes. In fission yeast, calcineurin is not essential for viability but is required for cytokinesis and Cl(-) homeostasis. In a genetic screen for mutations that are synthetically lethal with calcineurin deletion, we isolated a mutant, cis1-1/apm1-1, an allele of the apm1(+) gene that encodes a homolog of the mammalian micro1A subunit of the clathrin-associated adaptor protein-1 (AP-1) complex. The cis1-1/apm1-1 mutant as… CONTINUE READING
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