Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration.

@article{Sansom2004LossOA,
  title={Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration.},
  author={Owen J Sansom and Karen Ruth Reed and Anthony J. Hayes and Heather Ireland and Hannah Brinkmann and Ian Paterson Newton and Eduard Batlle and Patricia Simon-Assmann and Hans Clevers and Inke Nathke and Alan R. Clarke and Douglas J Winton},
  journal={Genes & development},
  year={2004},
  volume={18 12},
  pages={1385-90}
}
Although Apc is well characterized as a tumor-suppressor gene in the intestine, the precise mechanism of this suppression remains to be defined. Using a novel inducible Ahcre transgenic line in conjunction with a loxP-flanked Apc allele we, show that loss of Apc acutely activates Wnt signaling through the nuclear accumulation of beta-catenin. Coincidentally, it perturbs differentiation, migration, proliferation, and apoptosis, such that Apc-deficient cells maintain a "crypt progenitor-like… CONTINUE READING
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