Loss of Angiotensin-Converting Enzyme 2 Accelerates Maladaptive Left Ventricular Remodeling in Response to Myocardial Infarction

@article{Kassiri2009LossOA,
  title={Loss of Angiotensin-Converting Enzyme 2 Accelerates Maladaptive Left Ventricular Remodeling in Response to Myocardial Infarction},
  author={Zamaneh Kassiri and Jiu-Chang Zhong and Danny Guo and Ratnadeep Basu and Xiuhua Wang and Peter P. Liu and James Scholey and Josef M. Penninger and Gavin Y. Oudit},
  journal={Circulation: Heart Failure},
  year={2009},
  volume={2},
  pages={446-455}
}
Background—Angiotensin-converting enzyme 2 (ACE2) is a monocarboxypeptidase that metabolizes Ang II into Ang 1-7, thereby functioning as a negative regulator of the renin-angiotensin system. We hypothesized that ACE2 deficiency may compromise the cardiac response to myocardial infarction (MI). Methods and Results—In response to MI (induced by left anterior descending artery ligation), there was a persistent increase in ACE2 protein in the infarct zone in wild-type mice, whereas loss of ACE2… 

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