Loss of Adenoviral Receptor Expression in Human Bladder Cancer Cells : A Potential Impact on the Efficacy of Gene Therapy 1

Abstract

There is great interest in the development of gene therapeutic strategies for the treatment of benign and malignant diseases. Recombinant adenovirus has a wide spectrum of tissue specificity and is an efficient vector delivery system. Successful gene delivery, however, requires viral entry into the target cells via specific receptor-mediated uptake… (More)

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