Loss of 9p leads to p16INK4A down-regulation and enables RB/E2F1-dependent cell cycle promotion in gastrointestinal stromal tumours (GISTs).

@article{Haller2008LossO9,
  title={Loss of 9p leads to p16INK4A down-regulation and enables RB/E2F1-dependent cell cycle promotion in gastrointestinal stromal tumours (GISTs).},
  author={Florian Haller and Christian L{\"o}bke and Markus Ruschhaupt and Scott B. Cameron and H R Schulten and Stefanie Schwager and Anja von Heydebreck and Bastian Gunawan and Claus Langer and Giuliano Ramadori and Holger Sueltmann and Annemarie Poustka and Ulrike Korf and L{\'a}szl{\'o} F{\"u}zesi},
  journal={The Journal of pathology},
  year={2008},
  volume={215 3},
  pages={253-62}
}
Loss of chromosome 9p is a reliable predictor of malignant behaviour in gastrointestinal stromal tumours (GISTs). p16INK4A located at 9p21 inhibits the CDK4/6/cyclin D complex from phosphorylating RB. Phosphorylation of RB through CDK4/6/cyclin D in early G(1) phase frees the transcription factor E2F1 from RB and enables mRNA transcription of genes essential for G(1)/S phase transition. This study aims to determine the impact of 9p loss on mRNA and protein expression of p16INK4A and further key… CONTINUE READING

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