Loss of 5-hydroxymethylcytosine is linked to gene body hypermethylation in kidney cancer

@article{Chen2016LossO5,
  title={Loss of 5-hydroxymethylcytosine is linked to gene body hypermethylation in kidney cancer},
  author={Ke Chen and Jing Zhang and Zhongqiang Guo and Qin Yun Ma and Zhengzheng Xu and Yuanyuan Zhou and Ziying Xu and Zhongwu Li and Yiqiang Liu and Xiongjun Ye and Xuesong Li and Bifeng Yuan and Yuwen Ke and Chuan He and Liqun Zhou and Jiang Liu and Weimin Ci},
  journal={Cell Research},
  year={2016},
  volume={26},
  pages={103-118}
}
Both 5-methylcytosine (5mC) and its oxidized form 5-hydroxymethylcytosine (5hmC) have been proposed to be involved in tumorigenesis. Because the readout of the broadly used 5mC mapping method, bisulfite sequencing (BS-seq), is the sum of 5mC and 5hmC levels, the 5mC/5hmC patterns and relationship of these two modifications remain poorly understood. By profiling real 5mC (BS-seq corrected by Tet-assisted BS-seq, TAB-seq) and 5hmC (TAB-seq) levels simultaneously at single-nucleotide resolution… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 2 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 24 extracted citations

Aberrant gene-specific DNA methylation signature analysis in cervical cancer.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine • 2017

References

Publications referenced by this paper.
Showing 1-10 of 43 references

Similar Papers

Loading similar papers…