Loss of 14q and 22q in gastrointestinal stromal tumors (pacemaker cell tumors).

@article{Breiner2000LossO1,
  title={Loss of 14q and 22q in gastrointestinal stromal tumors (pacemaker cell tumors).},
  author={J A Breiner and Jeanne M. Meis-Kindblom and L. G. Kindblom and E. C. McComb and Jian Liu and Marilu Nelson and Julia A. Bridge},
  journal={Cancer genetics and cytogenetics},
  year={2000},
  volume={120 2},
  pages={111-6}
}
Gastrointestinal stromal tumors (GISTs), also referred to as "gastrointestinal pacemaker cell tumors (GIPACT)" are mesenchymal neoplasms that are phenotypically similar to the interstitial cells of Cajal (ICC). Cytogenetic studies of this entity are rare and molecular cytogenetic studies utilizing chromosome-specific probes are nonexistent. In the current study, cytogenetic and molecular cytogenetic analysis of 12 histologically and immunohistochemically confirmed GISTs revealed loss of a whole… CONTINUE READING
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