Loss- and gain-of-function analysis of the lipid raft proteins Reggie/Flotillin in Drosophila: they are posttranslationally regulated, and misexpression interferes with wing and eye development.

@article{Hoehne2005LossAG,
  title={Loss- and gain-of-function analysis of the lipid raft proteins Reggie/Flotillin in Drosophila: they are posttranslationally regulated, and misexpression interferes with wing and eye development.},
  author={Martin Hoehne and Heinz Gert de Couet and Claudia A.O. Stuermer and Karl-Friedrich Fischbach},
  journal={Molecular and cellular neurosciences},
  year={2005},
  volume={30 3},
  pages={326-38}
}
Reggie/Flotillin proteins are upregulated after optic nerve dissection and evolutionary highly conserved components of lipid rafts. Whereas many biochemical and cell culture studies suggest an involvement in the assembly of multiprotein complexes at cell contact sites, not much is known about their biological in vivo functions. We therefore set out to study… CONTINUE READING