Loss and Recovery of Genetic Diversity in Adapting Populations of HIV

  title={Loss and Recovery of Genetic Diversity in Adapting Populations of HIV},
  author={Pleuni Simone Pennings and Sergey Kryazhimskiy and John Wakeley},
  booktitle={PLoS genetics},
The evolution of drug resistance in HIV occurs by the fixation of specific, well-known, drug-resistance mutations, but the underlying population genetic processes are not well understood. By analyzing within-patient longitudinal sequence data, we make four observations that shed a light on the underlying processes and allow us to infer the short-term effective population size of the viral population in a patient. Our first observation is that the evolution of drug resistance usually occurs by… CONTINUE READING
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