Losing your nerves? Maybe it's the antibodies

  title={Losing your nerves? Maybe it's the antibodies},
  author={Betty Diamond and Patricio T. Huerta and Paola Mina-Osorio and Czeslawa Kowal and Bruce T. Volpe},
  journal={Nature Reviews Immunology},
We propose that the normal immunocompetent B cell repertoire is replete with B cells making antibodies that recognize brain antigens. Although B cells that are reactive with self antigen are normally silenced during B cell maturation, the blood–brain barrier (BBB) prevents many brain antigens from participating in this process. This enables the generation of a B cell repertoire that is sufficiently diverse to cope with numerous environmental challenges. It requires, however, that the integrity… CONTINUE READING
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