Losing protein in the brain: the case of progranulin.

  title={Losing protein in the brain: the case of progranulin.},
  author={Roberta Ghidoni and Anna Paterlini and Valentina Albertini and Giuliano Binetti and Luisa Benussi},
  journal={Brain research},
It is well known that progranulin protein is involved in wound repair, inflammation, and tumor formation. The wedding between progranulin and brain was celebrated in 2006 with the involvement of progranulin gene (GRN) in Frontotemporal lobar degeneration (FTLD), the most common form of early-onset dementia: up to date, 75 mutations have been detected in FTLD patients as well as in patients with widely variable clinical phenotypes. All pathogenic GRN mutations identified thus far cause the… CONTINUE READING

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