Losing Control: Excessive Alcohol Seeking after Selective Inactivation of Cue-Responsive Neurons in the Infralimbic Cortex.

@article{Pfarr2015LosingCE,
  title={Losing Control: Excessive Alcohol Seeking after Selective Inactivation of Cue-Responsive Neurons in the Infralimbic Cortex.},
  author={Simone Pfarr and Marcus W Meinhardt and Manuela L Klee and Anita C Hansson and Valentina Vengeliene and K. H. Sch{\"o}nig and Dusan Bartsch and Bruce T Hope and Rainer Spanagel and Wolfgang H. Sommer},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2015},
  volume={35 30},
  pages={10750-61}
}
UNLABELLED Loss of control over drinking is a key deficit in alcoholism causally associated with malfunction of the medial prefrontal cortex (mPFC), but underlying molecular and cellular mechanisms remain unclear. Cue-induced reinstatement of alcohol seeking activates a subset of mPFC neurons in rats, identified by their common expression of the activity marker cFos and comprised of both principal and interneurons. Here, we used cFos-lacZ and pCAG-lacZ transgenic rats for activity-dependent or… CONTINUE READING
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