Losartan treatment normalizes renal sodium and water handling in rats with mild congestive heart failure.

@article{Staahltoft2002LosartanTN,
  title={Losartan treatment normalizes renal sodium and water handling in rats with mild congestive heart failure.},
  author={Dennis Staahltoft and S\oren Lyhne Nielsen and Nadeem Rezaq Janjua and Sten Christensen and Ole Sk\ott and Niels Marcussen and Thomas E. N. Jonassen},
  journal={American journal of physiology. Renal physiology},
  year={2002},
  volume={282 2},
  pages={F307-15}
}
This study was designed to examine the effect of losartan treatment on renal tubular function in rats with mild congestive heart failure (CHF) induced by ligation of the left anterior descending artery. In rats with CHF, there was a significant decrease in daily sodium excretion, which caused sodium retention relative to control rats. Renal function studies revealed that glomerular filtration rate and proximal tubular sodium handling were normal. However, expression of the Na(+)-K(+)-2Cl… CONTINUE READING

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Acute effects F314 RENAL FUNCTION IN EXPERIMENTAL HEART FAILURE AJP-Renal Physiol

BM Christensen, D Marples, +4 authors S. Nielsen
Am J Physiol Renal Physiol 275: F285–F297, • 2002
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