Losartan prevents contractile dysfunction in rat myocardium after left ventricular myocardial infarction.

@article{Danils2001LosartanPC,
  title={Losartan prevents contractile dysfunction in rat myocardium after left ventricular myocardial infarction.},
  author={M. C. Dani{\"e}ls and Rebecca S. Keller and Pieter P de Tombe},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2001},
  volume={281 5},
  pages={
          H2150-8
        }
}
We studied the effects of chronic losartan (Los) treatment on contractile function of isolated right ventricular (RV) trabeculae from rat hearts 12 wk after left ventricular (LV) myocardial infarction (MI) had been induced by ligation of the left anterior descending artery at 4 wk of age. After recovery, one-half of the animals were started on Los treatment (MI+Los; 30 mg x kg(-1) x day(-1) per os); the remaining animals were not treated (MI group). Rats without infarction or Los treatment… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 37 REFERENCES

Agedependent changes in myosin composition correlate with enhanced economy of contraction in guinea-pig hearts

J Van der Velden, AF Moorman, GJ. Stienen
  • J Physiol (Lond)
  • 1998
VIEW 3 EXCERPTS