Losartan attenuates renal interstitial fibrosis and tubular cell apoptosis in a rat model of obstructive nephropathy.

@article{He2014LosartanAR,
  title={Losartan attenuates renal interstitial fibrosis and tubular cell apoptosis in a rat model of obstructive nephropathy.},
  author={Ping He and Detian Li and Beiru Zhang},
  journal={Molecular medicine reports},
  year={2014},
  volume={10 2},
  pages={
          638-44
        }
}
Ureteral obstruction leads to renal injury and progresses to irreversible renal fibrosis, with tubular cell atrophy and apoptosis. There is conflicting evidence concerning whether losartan (an angiotensin II type I receptor antagonist) mitigates renal interstitial fibrosis and renal tubular epithelial cell apoptosis following unilateral ureteral obstruction (UUO) in animal models. The aim of this study was to investigate the effect and mechanism of losartan on renal tubular cell apoptosis and… 
View on PubMed
spandidos-publications.com
15 Citations
Background Citations
3
Methods Citations
1

15 Citations

Citation Type

Citation Type

Thymoquinone ameliorates renal damage in unilateral ureteral obstruction in rats.
Effect of Shenkang on renal fibrosis and activation of renal interstitial fibroblasts through the JAK2/STAT3 pathway
TLDR
It is found that Shenkang regulated the JAK2/STAT3 pathway regulators peroxiredoxin 5 (Prdx5) in vitro and suppressor of cytokine signaling protein 1 (SOCS1) and SOCS3 in vivo, which may be a mechanism underlying its protective action in renal fibrosis.
Mefunidone ameliorates renal inflammation and tubulointerstitial fibrosis via suppression of IKKβ phosphorylation.
Functional and molecular evaluation of using aliskiren during acute and chronic partial ureteral obstruction in rat solitary kidney.
Tengdan Capsule Prevents Hypertensive Kidney Damage in SHR by Inhibiting Periostin-Mediated Renal Fibrosis
TLDR
In vivo study using rats showed that TDC effectively reduced BP, BUN, and CRE levels and attenuated renal fibrosis in SHR, and ameliorated damage to the kidneys.
Protective effects of ghrelin on kidney tissue in rats with partial ureteral obstruction
TLDR
Ghrelin administration to rats after the formation of an experimental partial unilateral ureteral obstruction reduces tissue damage due to ghrelin’s antiinflammatory and antioxidant effects, and may prevent tissue damage biochemically and histopathologically in obstructive uropathy cases.
m6A-induced lncRNA MALAT1 aggravates renal fibrogenesis in obstructive nephropathy through the miR-145/FAK pathway
TLDR
It was found that transforming growth factor beta 1 induced epithelial-mesenchymal transition (EMT) and extracellular matrix (ECM) protein deposition, which promoted the viability, proliferation and migration of human renal proximal tubular epithelial (HK2) cells.
Anti-Fibrotic Effect of Losartan, an Angiotensin II Receptor Blocker, Is Mediated through Inhibition of ER Stress via Up-Regulation of SIRT1, Followed by Induction of HO-1 and Thioredoxin
TLDR
Findings provide new insights into renoprotective effects of losartan and suggest that SIRT1, HO-1, and thioredoxin may be potential pharmacological targets in kidney diseases under excessive ER stress condition.
Transcriptomic analysis of the mechanisms of alleviating renal interstitial fibrosis using the traditional Chinese medicine Kangxianling in a rat model
TLDR
The potential mechanism of the Chinese medicine Kangxianling in inhibiting renal interstitial fibrosis is revealed and supported the clinical use of KXL in the treatment of kidney fibrosis.
Orally active, species-independent novel A3 adenosine receptor antagonist protects against kidney injury in db/db mice
TLDR
The results suggest that LJ-2698, a selective A3AR antagonist, may become a novel therapeutic agent against DKD, and may prove an invaluable drug, particularly in combination with an existing DKD drug.
...
1
2
...

References

SHOWING 1-10 OF 27 REFERENCES
Effect of unilateral ureteral obstruction and anti-angiotensin II treatment on renal tubule and interstitial cell apoptosis in rats.
Angiotensin receptor blockade decreases fibrosis and fibroblast expression in a rat model of unilateral ureteral obstruction.
AT1 receptor blockade prevents interstitial and glomerular apoptosis but not fibrosis in pigs with neonatal induced partial unilateral ureteral obstruction.
TLDR
It is demonstrated that ANG II plays a role in PUUO-induced glomerular cell apoptosis, suggesting that pathways not involving AT(1) receptor stimulation contribute to neonatal obstruction-induced fibrosis or that prevention of interstitialcell apoptosis counteracts a potential antifibrotic effect of AT( 1) receptor blockade in this pig model of congenital obstructive nephropathy.
Antibody to transforming growth factor-beta ameliorates tubular apoptosis in unilateral ureteral obstruction.
TLDR
It is strongly suggested that an antibody to TGF-beta is a promising agent to prevent renal tubular fibrosis and apoptosis in UUO.
Delayed Administration of Suramin Attenuates the Progression of Renal Fibrosis in Obstructive Nephropathy
TLDR
Suramin treatment prevents the onset of renal fibrosis in a model of obstructive nephropathy induced by unilateral ureteral obstruction and suggests the potential clinical application of suramin as an antifibrotic treatment in patients with chronic kidney disease.
Hepatocyte growth factor gene therapy and angiotensin II blockade synergistically attenuate renal interstitial fibrosis in mice.
TLDR
The results suggest that many factors are implicated in the pathogenesis of renal interstitial fibrosis; therefore, a combined therapy aimed at simultaneously targeting multiple pathologic pathways may be necessary for halting the progression of chronic renal diseases.
Angiotensin II receptor antagonist ameliorates renal tubulointerstitial fibrosis caused by unilateral ureteral obstruction.
TLDR
It is indicated that the renin-angiotensin system has a major role in the pathogenesis of the tubulointerstitial fibrosis of obstructive nephropathy.
Angiotensin AT1-receptor inhibition exacerbates renal injury resulting from partial unilateral ureteral obstruction in the neonatal rat.
TLDR
It is concluded that selective inhibition of AT(1) receptors during nephrogenesis (but not during subsequent renal maturation) exacerbates injury to the obstructed kidney and also injures the contralateral kidney.
Inhibition of histone deacetylase activity attenuates renal fibroblast activation and interstitial fibrosis in obstructive nephropathy.
TLDR
It is suggested that pharmacological HDAC inhibition may induce antifibrotic activity by inactivation of renal interstitial fibroblasts and inhibition of renal tubular cell death and STAT3 may mediate those actions of HDACs.
Modulation of apoptotic and inflammatory genes by bioflavonoids and angiotensin II inhibition in ureteral obstruction.
...
1
2
3
...