Losartan antagonism of angiotensin-II-induced potassium secretion across rat colon

@article{Hatch1998LosartanAO,
  title={Losartan antagonism of angiotensin-II-induced potassium secretion across rat colon},
  author={Marguerite Hatch and Robert W. Freel and Nosratola D. Vaziri},
  journal={Pfl{\"u}gers Archiv},
  year={1998},
  volume={436},
  pages={717-724}
}
 The effect of angiotensin II (ANG II) on potassium transport across the short-circuited rat distal colon was investigated using 86Rb+ as a tracer for unidirectional K+ fluxes. The addition of high concentrations of ANG II (≥10–6 M) to the serosal bathing solution had no effect on the mucosal to serosal flux of Rb+, but significantly increased the serosal to mucosal flux and abolished the basal net absorptive Rb+ flux. These ANG-II-induced alterations in Rb+ transport were blocked by the AT1… CONTINUE READING